DISEASE AREA
DISEASE AREA

Disease Areas

Cancer Cases

Liver and stomach cancers remain deadly without cure

  • Liver and stomach cancers: second and third leading cause of cancer deaths
  • Kills >1 million per year in China and Asia
  • Current standard treatment: Surgery, chemotherapy, radiation and/or targeted therapy – expensive, unpleasant side effects and limited benefits

2012

Development and Progression of HCC

  • Liver cancer is caused by multiple risk factors including viral hepatitis, fatty liver, NASH, alcoholics, and metabolic disorders, etc.
  • Chronic liver diseases (such as hepatitis, fibrosis and cirrhosis) may lead to liver cancer development
  • Many liver cancer patients die of tumor metastasis and recurrence

Liver Cancer

HBV infection is a major risk factor for liver cancer in Chinese patients

  • Patients in the 50s and elders (without effective prevention and vaccination) are high-risk HBV carriers
  • Current drugs are only effective to suppress the virus, but not able to cure or eliminate the HBV
  • HBV integration into patient genome is a key mechanism to drive liver cancer development. We are among the first group to decode HBV integration into the human genome using translational medicine platform and NGS technology (see Nature Genetic 2012).
  • This big-data knowledge allows scientists to better attack HBV and/or intercept HBV integration


Solution

  • Detect cancers early by cutting-edge genetic screening test (filling patent)
  • Identify targets that are unique in tumor tissues but not in healthy organs (patent issued)
  • Design and construct antibody-targeted therapeutics (patent filed)
  • Engineer and boost host immune cells to target and eliminate cnacer cells (patent filed)
  • Big data and eMedicine health (potential partners)