Research Publications
Research Publications

Innovative Discovery and Research Integrity are the spirit of Arbele's co-founders in advancing scientific knowledge and understanding of diseases. Without compromising the intellectual proprietary, we strive to publish the highest quality of research articles in the public domains.

Our Track Record on Drug Discovery

A small molecule inhibitor of PI3K delta is now an FDA approved drug for cancer

Our founder discovered, validated and developed the drug Idelalisib which was later acquired by Gilead for development to treat leukemia.

Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement
Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE.
J Immunol. 2003 Mar 1;170(5):2647-54.


(Citation Sources from Google Scholars as of Oct 31, 2016)

Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma.

Wong KF, Liu AM, Hong W, Xu Z, Luk JM.
Oncotarget. 2016 Oct 19. doi: 10.18632/oncotarget.12760.

An alternative DNA damage pathway to apoptosis in hematological cancers.

Luk JM, Guan KL.
Nat Med. 2014;20(6):587-8. doi: 10.1038/nm.3593.

Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.

Kim JH, Sohn BH, Lee HS, Kim SB, Yoo JE, Park YY, Jeong W, Lee SS, Park ES, Kaseb A, Kim BH, Kim WB, Yeon JE, Byun KS, Chu IS, Kim SS, Wang XW, Thorgeirsson SS, Luk JM, Kang KJ, Heo J, Park YN, Lee JS.
PLoS Med. 2014;11(12):e1001770. doi: 10.1371/journal.pmed.1001770.

Citations: 13

Diverse modes of genomic alteration in hepatocellular carcinoma.

Jhunjhunwala S, Jiang Z, Stawiski EW, Gnad F, Liu J, Mayba O, Du P, Diao J, Johnson S, Wong KF, Gao Z, Li Y, Wu TD, Kapadia SB, Modrusan Z, French DM, Luk JM, Seshagiri S, Zhang Z.
Genome Biol. 2014;15(8):436. doi: 10.1186/s13059-014-0436-9.

Citations: 21

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma.

Kan Z, Zheng H, Liu X, Li S, Barber TD, Gong Z, Gao H, Hao K, Willard MD, Xu J, Hauptschein R, Rejto PA, Fernandez J, Wang G, Zhang Q, Wang B, Chen R, Wang J, Lee NP, Zhou W, Lin Z, Peng Z, Yi K, Chen S, Li L, Fan X, Yang J, Ye R, Ju J, Wang K, Estrella H, Deng S, Wei P, Qiu M, Wulur IH, Liu J, Ehsani ME, Zhang C, Loboda A, Sung WK, Aggarwal A, Poon RT, Fan ST, Wang J, Hardwick J, Reinhard C, Dai H, Li Y, Luk JM, Mao M.
Genome Res. 2013:1422-33. doi: 10.1101/gr.154492.113.

Citations: 166

Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

Yong KJ, Gao C, Lim JS, Yan B, Yang H, Dimitrov T, Kawasaki A, Ong CW, Wong KF, Lee S, Ravikumar S, Srivastava S, Tian X, Poon RT, Fan ST, Luk JM, Dan YY, Salto-Tellez M, Chai L
N Engl J Med. 2013; 368(24):2266-76. doi: 10.1056/NEJMoa1300297.

Citations: 107

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

WK Sung, H Zheng, S Li, R Chen, X Liu, Y Li, NP Lee, WH Lee, ... J Wang, JM Luk
Nature genetics 2012; 44 (7), 765-769

Citations: 309

Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.

Lam SP, Luk JM, Man K, Ng KT, Cheung CK, Rose-John S, Lo CM.
Liver Transpl. 2010 Oct;16(10):1195-206. doi: 10.1002/lt.22136.

Citations: 47

Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma.

Lee NP, Poon RT, Shek FH, Ng IO, Luk JM.
Biochim Biophys Acta. 2010 Dec;1806(2):138-45. doi: 10.1016/j.bbcan.2010.05.002.

Citations: 41

Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma.

Liu LX, Lee NP, Chan VW, Xue W, Zender L, Zhang C, Mao M, Dai H, Wang XL, Xu MZ, Lee TK, Ng IO, Chen Y, Kung HF, Lowe SW, Poon RT, Wang JH, Luk JM.
Hepatology. 2009 Nov;50(5):1453-63. doi: 10.1002/hep.23143. Erratum in: Hepatology. 2010 Jan;51(1):358.

Citations: 96

Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice.

Beier JI, Luyendyk J, Guo L, von Montfort C, Staunton DE, Arteel GE.
Hepatology 2009; 49:1545-53.

Citations: 52

Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma

Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT, Luk JM.
Cancer 2009; 115 (19), 4576-4585

Citations: 282

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

Zender L, W Xue, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, Lowe SW.
Cell 2008; 135 (5), 852-864

Citations: 334

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23. 3

IPM Tomlinson, E Webb, L Carvajal-Carmona, P Broderick, K Howarth, ...
Nature genetics 2008; 40 (5), 623-630

Citations: 468

Targeting integrin structure and function in disease.

Staunton, DE., Lupher, ML., Liddington, R. and Gallatin, WM
Advances in Immunology 2006;91:111-57

Citations: 47

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW.
Cell 2006; 125 (7), 1253-1267

Citations: 778

Kinetics and risk of de novo hepatitis B infection in HBsAg–negative patients undergoing cytotoxic chemotherapy

CK Hui, WWW Cheung, HY Zhang, WY Au, YH Yueng, AYH Leung, ...
Gastroenterology 2006; 131 (1), 59-68

Citations: 393

Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma.

Wang XQ, Luk JM, Garcia-Barcelo M, Miao X, Leung PP, Ho DW, Cheung ST, Lam BY, Cheung CK, Wong AS, Lau SS, So MT, Cai Q, Liu KS, Hui CK, Lau GK, Poon RT, Wong J, Fan ST.
Clin Cancer Res. 2006 Sep 1;12(17):5248-52.

Citations: 34

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines.

Shamri R, Grabovsky V, Gauguet JM, Feigelson S, Manevich E, Kolanus W, Robinson MK, Staunton DE, von Andrian UH, Alon R.
Nature Immunology 2005; 6: 497-506.

Citations: 331

Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases

XM Yu, CY Lo, WF Chan, KY Lam, P Leung, JM Luk
Clinical Cancer Research 2005; 11 (22), 8063-8069

Citations: 129

Hepatic potential of bone marrow stromal cells: development of in vitro co-culture and intra-portal transplantation models

JM Luk, PP Wang, CK Lee, JH Wang, ST Fan.
Journal of immunological methods 2005; 305 (1), 39-47

Citations: 133

CDX2 co‐localizes with liver–intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach

S Ko, KM Chu, JMC Luk, BWY Wong, ST Yuen, SY Leung, J Wong
The Journal of pathology 2005; 205 (5), 615-622

Citations: 59

Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma

XQ Wang, JM Luk, PP Leung, BW Wong, EJ Stanbridge, ST Fan
Clinical Cancer Research 2005; 11 (2), 483-489

Citations: 72

Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation.

Bhattacharya AA, Lupher ML Jr, Staunton DE, Liddington RC.
Structure (Camb) 2004, 3: 371-378.

Citations: 34

Identification of liver-intestine cadherin in hepatocellular carcinoma--a potential disease marker.

BW Wong, JM Luk, IO Ng, MY Hu, KD Liu, ST Fan
Biochemical and biophysical research communications 2003; 311 (3), 618-624

Citations: 83

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement.

Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE.
J Immunol. 2003;170(5):2647-54.

Citations: 353

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML, Wilson A, Fesik S, Staunton DE.
Proc Natl Acad Sci U S A. 2000; 97(10):5231-6.

Citations: 167

A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.

Van der Vieren M, Le Trong H, Wood CL, Moore PF, St John T, Staunton DE, Gallatin WM.

Immunity. 1995 Dec;3(6):683-90.

Citations: 278

Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus.

Ockenhouse CF, Betageri R, Springer TA, Staunton DE.
Cell 1992; 68: 63-69.

Citations: 174

CD43 interferes with T-lymphocyte adhesion.

Ardman B, Sikorski MA, Staunton DE.

Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5001-5.

Citations: 168

Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, and maps to chromosome 1q21-23.

Staunton DE, Fisher RC, LeBeau MM, Lawrence JB, Barton DE, Francke U, Dustin M, Thorley-Lawson DA.

J Exp Med. 1989 Mar 1;169(3):1087-99.

Citations: 70

A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.

Staunton DE, Merluzzi VJ, Rothlein R, Barton R, Marlin SD, Springer TA.
Cell 1989; 56: 849-53.

Citations: 769

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.

Staunton DE, Dustin ML, Springer TA
Nature. 1989; 339: 61-64.

Citations: 899

Supergene families meet in the immune system.

Dustin ML, Staunton DE, Springer TA.

Immunol Today. 1988 Jul-Aug;9(7-8):213-5.

Citations: 237

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.

Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA.
Cell 1988; 52: 925-933.

Citations: 950